STAT3 Inhibitor V, Stattic – CAS 19983-44-9 – Calbiochem
REF : 573099-25MG
Marca : Sigma-Aldrich
Descrição :STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.
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Categoria : Small Molecules
Descrição detalhada : A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
Sinónimos : STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem; 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
Fórmula molecula r: C8H5NO4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG
Sinónimos : STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem; 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
Fórmula molecula r: C8H5NO4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X25MG