STAT3 Inhibitor XII, SPI – Calbiochem

Descrição detalhada : The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications., A cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
Sinónimos : STAT3 Inhibitor XII, SPI - Calbiochem
Fórmula molecula r: C146H238N40O42
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG