TGF-beta RI Kinase Inhibitor – CAS 396129-53-6 – Calbiochem

REF : 616451-5MG
Marca : Sigma-Aldrich
Descrição :TGF-beta RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem The TGF-beta RI Kinase Inhibitor, also referenced under CAS 396129-53-6, controls the biological activity of TGF-beta RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable, a potent, selective, reversible, and ATP-competitive inhibitor of TGF-b RI serine/threonine kinase (IC50 = 51 nM). Displays ~15-fold greater selectivity over p38alpha MAP kinase (IC50 = 740 nM). Reported to inhibit TGF-b-dependent cellular growth (IC50 = 89 nM in mouse NIH3T3 fibroblasts) and transcription activation (IC50 = 47 nM in mink lung cells)., A cell-permeable diheteroaryl-substituted pyrazole compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-beta Receptor I kinase (IC50 = 51 nM). Displays ~15-fold greater selectivity over p38alpha MAP kinase (IC50 = 740 nM). Shown to inhibit TGF-beta-dependent cellular growth (IC50 = 89 nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50 = 47 nM in mink lung cells).
Sinónimos : TGF-beta RI Kinase Inhibitor - CAS 396129-53-6 - Calbiochem; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor, ALK5 Inhibitor I, [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole, TbetaR-I Inhibitor, LY-364947, HTS-466284; [3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole, TbetaR-I Inhibitor, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor, ALK5 Inhibitor I, LY-364947, HTS-466284
Fórmula molecula r: C17H12N4
Armazenamento : 2-8C; 2-8C
Embalagem : 1X5MG