TGF-beta RI Kinase Inhibitor II – CAS 446859-33-2 – Calbiochem

REF : 616452-2MG
Marca : Sigma-Aldrich
Descrição :TGF-beta RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem TGF-beta RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-beta R1 kinase (IC?? = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).
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Descrição detalhada : A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-beta type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-beta cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM)., A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-beta type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-beta cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 >16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).
Sinónimos : TGF-beta RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem; ALK5 Inhibitor II, Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Fórmula molecula r: C17H13N5
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X2MG