TGF-beta RI Kinase Inhibitor IV – CAS 909910-43-6 – Calbiochem
REF : 616454-2MG
Marca : Sigma-Aldrich
Descrição :TGF-beta RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem TGF-beta RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC?? = 45, 12, and 7.5 nM, respectively).
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Categoria : Small Molecules
Descrição detalhada : A cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-beta receptors. Inhibits TGF-beta-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
Sinónimos : TGF-beta RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
Fórmula molecula r: C25H19N5S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X2MG
Sinónimos : TGF-beta RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem; Transforming Growth Factor-beta Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
Fórmula molecula r: C25H19N5S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X2MG