Wnt Antagonist III, Box5 – Calbiochem

REF : 681673-10MG
Marca : Sigma-Aldrich
Descrição :Wnt Antagonist III, Box5 - Calbiochem The Wnt Antagonist III, Box5 controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
Clique para mais informações
Categoria :
Descrição detalhada : A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Sinónimos : Wnt Antagonist III, Box5 - Calbiochem; Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist, Wnt-5a Antagonist
Fórmula molecula r: C30H50N6O13S2
Armazenamento : -20C
Embalagem : 1X10MG