Wnt Pathway Inhibitor XI, CCT036477 – CAS 305372-78-5 – Calbiochem

REF : 681674-5MG
Marca : Sigma-Aldrich
Descrição :Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem The Wnt Pathway Inhibitor XI, CCT036477, also referenced under CAS 305372-78-5, controls the biological activity of Wnt Pathway. This small molecule/inhibitor is primarily used for Cancer applications.
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Descrição detalhada : A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering beta-catenin accumulation but by blocking transcription at the beta-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
Sinónimos : Wnt Pathway Inhibitor XI, CCT036477 - CAS 305372-78-5 - Calbiochem; CCT036477, CRT Inhibitor VI, beta-Catenin/Tcf Inhibitor VI
Fórmula molecula r: C21H18ClN3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG