JNK Inhibitor III, Cell-Permeable – Calbiochem

Descrição detalhada : A cell-permeable 37 amino acid peptide constructed by fusing the JNK binding domain sequence (delta) (amino acids 33-57) of human c-Jun to the HIV-TAT transduction domain sequence (amino acids 47-57) with a gamma-aminobutyric acid (GABA) spacer. Reported to specifically disrupt c-Jun/JNK complex formation and subsequent phosphorylation and activation of c-Jun by JNK in vitro and in intact cells. Also reported to induce apoptosis in HeLa cells. Mode of inhibition is distinct from that of JNK Inhibitor II (SP600125; Cat. No. 420119), so may complement this inhibitor in JNK pathway studies., A cell-permeable 37-mer peptide constructed by fusing human c-Jun delta domain (amino acids 33-57) sequence with that of HIV-TAT protein transduction domain (amino acids 47-57) via a gamma-aminobutyric acid (GABA) spacer. Shown to specifically disrupt c-Jun/JNK complex formation and the subsequent phosphorylation and activation of c-Jun by JNK both in vitro and in intact cells. Since its mode of inhibition is different than that of JNK Inhibitor II (SP600125; Cat. No. 420119), these two inhibitors can complement each other in JNK signaling pathway studies.
Sinónimos : JNK Inhibitor III, Cell-Permeable - Calbiochem; HIV-TAT?????-gaba-c-Jundelta?????, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH?, SAPK Inhibitor III; SAPK Inhibitor III, HIV-TAT?????-gaba-c-Jundelta?????, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂
Fórmula molecula r: C191H336N70O48S
Armazenamento : -20C
Embalagem : 1X1MG