Pifithrin-alpha, p-Nitro, Cyclic – CAS 60477-38-5 – Calbiochem

Descrição detalhada : A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37C) than Pifithrin-alpha (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-alpha, p-Nitro (Cat. No. 506152)., A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37C) than Pifithrin-alpha (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-alpha, p-Nitro (Cat. No. 506152).
Sinónimos : Pifithrin-alpha, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem; 2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole
Fórmula molecula r: C15H13N3O2S
Armazenamento : -20C
Embalagem : 1X5MG